Kinam Park, Ph.D. Professor of Pharmaceutics & Biomedical Engineering Purdue University School of Pharmacy West Lafayette, IN 47907 Tel: 765) 494-7759; Fax: 765) 496-1903 E-mail: kpark@purdue.edu B.S. in Pharmacy, Seoul National University, 1971-75 Lieutenant in the Korean Army, 1975-1977 Ph.D. in Pharmaceutics, University of Wisconsin, 1979-83 Postdoc in Chem. Eng., University of Wisconsin, 1983-85

Teaching

• IPPH 363: Basic Pharmaceutics II: Controlled Drug Delivery
  Course Outline:
  1. Pharmaceutics and Drug Delivery Systems
  2. Polymers used in Pharmaceutics
  3. Solid Dosage Forms: Powders and Granules
  4. Solid Dosage Forms: Capsules
  5. Solid Dosage Forms: Tablets
  6. Fundamentals of Controlled Release Drug Delivery
  7. Design of Controlled Release Devices
  8. Mathematical Concepts of Controlled Release
  9. Mechanisms of Controlled Release
  10. Routes of Drug Delivery
  11. Drug Targeting
  12. Modulated Drug Delivery Systems
  13. Regulatory Considerations in Controlled Drug Delivery
  
  
• IPPH 690W (BME 695K):Polymers in Pharmaceutical & Biomedical Systems
  Course Outline
  1. Introduction to Polymers
  2. Polymer Synthesis & Polymer Properties
  3. Polymers in Biomaterials
  4. Polymers in Biotechnology
  5. Smart Polymers & Hydrogels
  6. Polymers in Pharmaceutics
  7. Polymers in Nanotechnology
  8. Polymers in Tissue Engineering and Cell Delivery
  9. Presentations on Polymer-related Topics

Research Interests

1. Solvent exchange method for microencapsulation of protein drugs

2. Hydrotropic polymers for delivery of poorly soluble drugs

3. Fast dissolving tablets

4. Drug loading on various types of stents

5. Oral dosage forms using superporous hydrogel microparticles

Books Published

1)   Park, K., Shalaby, S.W.S., and Park, H.: Biodegradable Hydrogels for Drug Delivery, Technomic Publishing Co., Inc., Lancaster, PA, 1993, 252 pages.

2)   Ottenbrite, R., Hwang, S., and Park, K., Eds.: Hydrogels and Biodegradable Polymers for Bioapplications (ACS Symposium Series 627), American Chemical Society, Washington, DC, 1996, 268 pages.

3)   Park, K., Ed.: Controlled Drug Delivery: Challenges and Strategies, American Chemical Society, Washington, DC, 1997, 629 pages.

4)   Park, K. and Mrsny, R., Eds.: Controlled Drug Delivery: Designing Technologies for the Future (ACS Symposium Series 752), American Chemical Society, Washington, DC, 2000, 459 pages.

5)   Park, K.D., Kwon, I.C., Yui, N., Jeong, S.Y. and Park, K., Eds.: Biomaterials and Drug Delivery toward New Millennium, Han Rim Won Publishing Co., Seoul, Korea, 2000, 691 pages.

6)   Park, K. Ed., Protein- and Cell-Repellent Surfaces, Colloids and Surfaces B: Biointerfaces, Elsevier Science, Vol. 18 (No. 3-4), 2000.

7)   Park, K., Ed., Recent Developments in Hydrogels, Advanced Drug Delivery Reviews, Elsevier Science,Vol. 54, 2001.

8)   Yui, N. and Park, K., Eds.: Flash polymers and hydrogels: Understanding and designing the fast-responsive polymeric systems, CRC Press, Boca Raton, FL, in preparation.

Recent Publications

Gemeinhart,R., Park, H., and Park, K.: Effect of compression on fast swelling of poly(acrylamide-co-acrylic Acid) superporous hydrogels, J. Biomed. Mater. Res. 55:54-62, 2001.

Li, T. and Park, K.: Monte Carlo simulation of grafted poly(ethylene oxide) chains, Computational and Theoretical Polymer Science, 11(2): 133-142, 2001.

Baek, N., Park, J.H., Bae, Y.H., and Park, K.: Control of swelling rate of superporous hydrogels, J. Bioact. Compat. Polymers, 16: 47-57, 2001.

Li, T., Morris, K., and Park, K.: Influence of tailor-made additives on etching patterns of acetaminophen single crystals, Pharm. Res , 18: 398-402, 2001.

Kim, J.J. and Park, K.: Glucose-binding property of PEGylated concanavalin A, Pharm. Res. 18:794-799, 2001.

Kim, J.J. and Park, K.: Immobilization of concanavalin A to glucose-containing polymers, Macromolecular Symposia, 172: 95-102, 2001.

Yeo, Y., Baek, N.J., and Park, K.: Microencapsulation methods for delivery of protein drugs, Biotechnol. Bioprocess Eng., 6:213-230, 2001.

Kim, J.J. and Park, K.: Modulated insulin delivery from glucose-sensitive hydrogel dosage forms, J. Controlled Rel. 77:39-47, 2001.

Park, K., Chen, J., and Park, H.: Superporous Hydrogel Composites: A New Generation of Hydrogels with Fast Swelling Kinetics, High Swelling Ratio and High Mechanical Strength, in Polymeric Drugs & Drug Delivery Systems, Ottenbrite, R.M., and Kim, S.W., Eds., Technomic Publishing Co., 2001, pp. 145-156.

Lee, J.H., Li, T., and Park, K.: Solvation interactions for protein adsorption to biomaterial surfaces, in Water in Biotechnological Surface Science, Morra, M. Ed., John Wiley & Sons, New York, 2001, pp. 127-146.

Lee, J.H. and Park, K.: Modification of natural polymers: Albumin, in Methods of Tissue Engineering, Atala, A. and Lanza, R., Eds., Academic Press, San Diego, CA, 2001, pp. 525-538.

Sa, H., Chien, Y.W., Park, H., Hwang, S.-J., Park, K., and Lloyd, A.W.: New generation technologies, in Drug Delivery and Targeting for Pharmacists & Pharmaceutical Scientists, Anya M. Hillery, A.M., Lloyd, A.W., and Swarbrick, J., Eds., Harwood Academic Publishers, 2001, pp. 421-441.

Qui, Y. and Park, K.: Environmentally-sensitive polymer hydrogels, in Triggered Release in Drug Delivery Systems, David H. Thompson, Ed., a theme issue of the journal Advanced Drug Delivery Reviews, 53: 321-339, 2001.

Kim, J.J. and Park, K.: Applications of smart hydrogels in separation, in Smart Polymers for Bioseparation and Bioprocessing, Mattiasson, B. and Galaev, I., Eds., Harwood Publishers, 2002, pp. 140-162.

Lee, J.H., Kim, J.J., and Park, K.: Glucose-sensitive hydrogel membranes, in Polymeric Biomaterials, Dumitriu, S., Ed., Marcel Dekker, Inc., New York, NY, 2002, pp. 739-752.

Mittal, S.K., HogenEsch, H., and Park, K.: Vaccines and other immunological products , in Encyclopedia of Pharmaceutical Technology, Swarbrick, J. and Boyland, J.C., Eds., Marcel Dekker, New York, NY, 2002, pp. 2895-2916.

Qui, Y. and Park, K.: Modulated drug delivery, in Supramolecular Design for Biological Applications, Yui, N., Ed., CRC Press, Boca Raton, 2002, pp. 227-243.

Li, T., Park, K., and Morris, K.R.: Understanding the formation of etching patterns using a refined Monte Carlo simulation model, Crystal Growth & Design, 2(3): 177-184, 2002.

Li, T., Wen, H., Park, K., and Morris, K.R.: How specific interactions between acetaminophen and its additive 4-methylacetanilide affect growth morphology: Elucidation using etching patterns, Crystal Growth & Design, 2(3): 185-189, 2002.

Seong, H., Lee, H.-B., and Park, K.: Glucose binding to molecularly imprinted polymers, J. Biomater. Scie. Polymer Edn.13: 637-649, 2002.

Seong, H., Choi, W.-M., Kim, J.-C., Thompson, D.H., and Park, K.: Binding of glucose by liposomes containing di-branched amino acid derivatives, Biomaterials, in press.

Graduate Students and Postdocs

Yourong Fu

Yong Qiu

Hong Wen

Yoon Yeo

Seonghoon Jeong

Eunah Kang

Kimberly Hayden (NSF IGERT Fellow, Co-advisor with Professor Jennifer Sinclair at Department of Chemical Engineering)

Connie Paul (NSF IGERT Fellow, Co-advisor with Professor Paul Robinson at School of Veterinary Sciences)

Grace Jun (NSF IGERT Fellow, Co-advisor with Professor Tom Webster at Department of Biomedical Engineering).

Jaehwi Lee, Ph.D.

Sang Cheon Lee, Ph.D.

Shi Cheng Yang, Ph.D.

Tooru Ooya, Ph.D.

Seon Haeng Cho, Ph.D.